2, 3-Dihydro-5-benzofuranols as antioxidant-based inhibitors of leukotriene biosynthesis

…, CG Caldwell, J Boger, F Baker, T Bach…

文献索引：Hammond; Kopka; Zambias; Caldwell; Boger; Baker; Bach; Luell; MacIntyre Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1006 - 1020

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被引用次数: 52

摘要

The enzymes that catalyze the oxidative metabolism of arachidonic acid have provided fertile ground for the development of useful therapeutic agents for nearly a quarter century. Inhibitors of the enzyme cyclooxygenase prevent the formation of the prostaglandins and thromboxanes and are clinically useful antiinflammatories and peripheral analgesics. More recently it has been discovered that the enzyme 5-lipoxygenase is the first step in the ...