Reversed-phase TLC and HPLC retention data in correlation studies with in silico molecular descriptors and druglikeness properties of newly synthesized …

N Perisic-Janjic, R Kaliszan, P Wiczling…

文献索引：Perisic-Janjic, Nada; Kaliszan, Roman; Wiczling, Pawel; Milosevic, Natasa; Uscumlic, Gordana; Banjac, Nebojsa Molecular Pharmaceutics, 2011 , vol. 8, # 2 p. 555 - 563

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被引用次数: 30

摘要

The properties relevant to pharmacokinetics of two series of newly synthesized succinimide derivatives have been studied. The properties under consideration have been either determined empirically, by reversed-phase liquid chromatography (TLC and HPLC technique), or calculated with the use of established theoretical medicinal chemistry/drug design software. Chromatographic techniques allowed determination of the retention ...