Synthesis and biological activity of alkylamides of 2-arylamino-6-methylnicotinic acids

…, NA Podushkina, VS Zalesov, ME Konshin

文献索引：Shramm, N. I.; Podushkina, N. A.; Zalesov, V. S.; Konshin, M. E. Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 4 p. 249 - 252 Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 4 p. 35 - 38

全文：HTML全文

被引用次数: 7

摘要

The synthesis of the starting 2, chloro-6-methylnicotinic acid alkylamides (I-IV) was accomplished by reaction of the acid chloride [2] with the alkylamines in solution in anhydrous ether in the presence of triethylamine. The alkylamides I-IV were reacted with the aryl amines by boiling in 50% acetic acid, yields of 40-61% of the 2-arylamino, 6- methylnicotinic acid alkylamides being obtained (V-XIII; Table i) as colorless crystalline ...