8-Hydroxy-2-(dipropylamino) tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist

LE Arvidsson, U Hacksell, JLG Nilsson…

文献索引：Arvidsson, Lars-Erik; Hacksell, Uli; Nilsson, J. Lars G.; Hjorth, Stephan; Carlsson, Arvid; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 8 p. 921 - 923

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被引用次数: 404

摘要

Now we report the pharmacological properties of 8-hydroxy-2-(di-n-propylamino) tetralin (8- OH-DPAT; 4) which are consistent with the characterization of this compound as a central 5- hydroxytryptamine (5-HT) receptor agonist, devoid of DA-receptor stimulating activity. The DA-receptor-active 2-aminotetralins (1-3) are included for comparative purposes in this study. We are also presenting the resolution of 4 and the testing results for the ...