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Synthesis and pharmacological properties of substituted cinnamohydroxamic acids

NP Buu-Hoi, CL Gillet, GE Lambelin…

文献索引:Buu-Hoi,N.P. et al. Journal of Medicinal Chemistry, 1970 , vol. 13, p. 211 - 213

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被引用次数: 12

摘要

Where Rr, H,= H, the starting material was phydroxybenzaldehyde (1-7, 36). Where R3= H and R?= F, C'l, Br, CH3 (8-13, 23-29), the starting material waa o-fluorophenol, o- chlorophenol, o-bromophenol, and o-cresol, which were alkylated by means of t'he appropriat'e alkyl halide. The corresponding aldehydes were then obtained either by chloromethylation followed by a Soninielet reaction, or directly by a Rieche reaction'O ( ...