Transition-metal-catalyzed cyclization of alkynoic acids to alkylidene lactones

…, TB Marder, D Milstein, NJ Taylor

文献索引：Chan, Dominic M. T.; Marder, Todd B.; Milstein, David; Taylor, Nicholas J. Journal of the American Chemical Society, 1987 , vol. 109, # 21 p. 6385 - 6388

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被引用次数: 86

摘要

Abstract: Alkynoic acids I-IV can be effectively cyclized to the corresponding exocyclic enol lactones with a new Rh (1) complex,[(cycph~ s) RhCl]~(4)(cycphos= 1, 2-bis ( dicyclohexylphosphino) ethane), that we have developed. The high-yield lactonizations can be performed at room temperature, and methylene chloride appears to be the best solvent for the cyclization. Exclusive