An efficient method to prepare 4??aminoquinazolines: Potential application to conformation??restricted bleomycin analogs

Z Wei, L Zheng, Q Dang, X Bai

文献索引：Wei, Zhonglin; Zheng, Lianyou; Dang, Qun; Bai, Xu Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 6 p. 1425 - 1429

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被引用次数: 2

摘要

Bleomycins are a family of glycopeptide natural products and have been used clinically to treat various cancers for decades. However, dose-dependent undesired side effects, such as pulmonary toxicity are limiting the therapeutic efficacy of bleomycins. Thus, it has been suggested that improved bleomycin analogs may have enhanced therapeutic index between anticancer activity and undesired toxicity [1]. The seminal studies by Hecht [2–4], ...