ParaCEST MRI contrast agents capable of derivatization via “click” chemistry

…, K Chicas, A Li, R Bartha, RHE Hudson

文献索引：Milne, Mark; Chicas, Kirby; Li, Alex; Bartha, Robert; Hudson, Robert H. E. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 2 p. 287 - 292

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被引用次数: 19

摘要

A comprehensive series of lanthanide chelates has been prepared with a tetrapropargyl DOTAM type ligand. The complexes have been characterized by a combination of 1H NMR, single-crystal X-ray crystallography, CEST and relaxation studies and have also been evaluated for potential use as paramagnetic chemical exchange saturation transfer (ParaCEST) contrast agents in magnetic resonance imaging (MRI). We demonstrate the ...