Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho [2, 3-d] isoxazole-4, 9-diones

…, J Iley, SJ Coles, MB Hursthouse, ML Martins…

文献索引：Santos, Maria M.M.; Faria, Natalia; Iley, Jim; Coles, Simon J.; Hursthouse, Michael B.; Martins, M. Luz; Moreira, Rui Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 193 - 195

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被引用次数: 63

摘要

We report here a simple entry into naphtho [2, 3-d] isoxazole-4, 9-dione system containing a EWG in position 3 using the readily available 2, 3-dichloro-1, 4-naphthoquinone and nitromethyl derivatives in the presence of base. Antifungal activity of synthesised naphthoquinones was evaluated against ATCC and PYCC reference strains of Candida. The results suggest that the naphtho [2, 3-d] isoxazole-4, 9-dione scaffold has the ...