Novel 1, 3, 5-triphenyl-2-pyrazolines as anti-infective agents

PM Sivakumar, SP Seenivasan, V Kumar…

文献索引：Sivakumar; Prabhu Seenivasan; Kumar, Vanaja; Doble, Mukesh Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 10 p. 3169 - 3172

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被引用次数: 55

摘要

Sixteen 1, 3, 5-triphenyl-2-pyrazolines were synthesized and their anti-infective activities (against Mycobacterium tuberculosis H37Rv, six bacterial and four fungal strains) were tested. Only compound with SO2CH3 in the para position of the A-ring was active against the tubercular strain at 100μg/ml concentration. All compounds showed good anti infective activity against Escherichia coli and poor activity against Staphylococcus aureus. ...