Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: Discovery of a quinazolinone chemotype

PL Beaulieu, R Coulombe, J Duan, G Fazal…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 14 p. 4132 - 4140

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被引用次数: 15

摘要

... Bioorganic & Medicinal Chemistry Letters. ... a Medicinal Chemistry, Boehringer Ingelheim ... In a parallel effort we also pursued structure-based design aiming to increase chemical diversity by replacing the carboxylic acid function of 1 by non-ionizable surrogates in order to identify ...