Synthesis and biological evaluation of 2, 3-diarylimidazo [1, 2-a] pyridines as antileishmanial agents

…, M Antoine, L Meijer, N Rachidi, P Le Pape

文献索引：Marhadour, Sophie; Marchand, Pascal; Pagniez, Fabrice; Bazin, Marc-Antoine; Picot, Carine; Lozach, Olivier; Ruchaud, Sandrine; Antoine, Maud; Meijer, Laurent; Rachidi, Najma; Le Pape, Patrice European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 543 - 556

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被引用次数: 23

摘要

A novel series of 2, 3-diarylimidazo [1, 2-a] pyridines was synthesized and evaluated for their antileishmanial activities. Four derivatives exhibited good activity against the promastigote and intracellular amastigote stages of Leishmania major, coupled with a low cytotoxicity against the HeLa human cell line. The impact of compound lipophilicity on antiparasitic activities was investigated by Log D comparison. Although LmCK1 could be ...