(1H-Imidazo [4, 5-c] pyridin-2-yl)-1, 2, 5-oxadiazol-3-ylamine derivatives: Further optimisation as highly potent and selective MSK-1-inhibitors

…, TA Panchal, CA Parr, S Sehmi, JG Steadman…

文献索引：Bamford, Mark J.; Bailey, Nicholas; Davies, Susannah; Dean, David K.; Francis, Leann; Panchal, Terence A.; Parr, Christopher A.; Sehmi, Sanjeet; Steadman, Jon G.; Takle, Andrew K.; Townsend, James T.; Wilson, David M. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3407 - 3411

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被引用次数: 29

摘要

The novel imidazo [4, 5-c] pyridine 1, 2, 5-oxadiazol-3-yl template affords an excellent start point for identification of inhibitors of a number of protein kinases. Here we report on its optimisation for mitogen and stress-activated protein kinase-1 (MSK-1) inhibitory activity, and selectivity over other kinases.