Studies of hypolipidemic agents. 1. Synthesis and hypolipidemic activities of alkoxycinnamic acid derivatives

T Watanabe, K Hayashi, S Yoshimatsu…

文献索引：Watanabe; Hayashi; Yoshimatsu; Sakai; Takeyama; Takashima Journal of Medicinal Chemistry, 1980 , vol. 23, # 1 p. 50 - 59

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被引用次数: 38

摘要

More than 110 derivatives of alkoxycinnamic acids were synthesized and their hypolipidemic activities were evaluated in a screening system with rats. Cinnamic acids, a- methylcinnamic acids, and their various esters with a higher p-alkoxy substituent were found to possess hypolipidemic activities higher than or comparable to that of clofibrate. The proper length (C12+ &) and the para position of the alkoxy substituent seem to be ...