Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as …

Y Huang, SA Bae, Z Zhu, N Guo, BL Roth…

文献索引：Huang, Yiyun; Bae, Sung-A; Zhu, Zhihong; Guo, Ningning; Roth, Bryan L.; Laruelle, Marc Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2559 - 2570

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被引用次数: 57

摘要

A series of new, fluorine-containing substituted diphenyl sulfides was synthesized to serve as candidate ligands for positron emission tomography (PET) imaging of the serotonin transporter (SERT) and to further probe the structure-activity relationship (SAR) of this class of compounds. Candidate compounds were assayed for their affinities to the monoamine transporters (SERT, norepinephrine transporter (NET), and dopamine transporter (DAT)) ...