Design and synthesis of oxime ethers of α-acyl-β-phenylpropanoic acids as PPAR dual agonists

HO Han, SH Kim, KH Kim, GC Hur, HJ Yim…

文献索引：Oon Han, Hee; Hae Kim, Seung; Kim, Kyoung-Hee; Hur, Gwong-Cheung; Joo Yim, Hyeon; Chung, Hee-Kyung; Ho Woo, Sung; Dong Koo, Ki; Lee, Chang-Seok; Sung Koh, Jong; Tae Kim, Geun Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 937 - 941

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被引用次数: 31

摘要

Oxime ethers of α-acyl-β-phenylpropanoic acids were prepared to apply as PPARα and γ dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC50 of 19 and 13nM in PPARα and γ, respectively. It showed better glucose lowering effects than rosiglitazone 1 and ameliorated the lipid profile like plasma triglyceride in db/db mice model.