Facile syntheses of building blocks for the construction of phosphotyrosine mimetics
GS Cockerill, HJ Easterfield, JM Percy…
文献索引：Cockerill, G. Stuart; Easterfield, Howard J.; Percy, Jonathan M.; Pintat, Stephane Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 16 p. 2591 - 2599
The copper-catalysed zinc phosphonate chemistry described by Yokomatsu and Shibuya can be used to enter the classical organometallic coupling repertoire via Stille and Suzuki– Miyaura couplings. 1, 4-Diiodobenzene underwent coupling with the organozinc reagent derived from diethyl bromodifluoromethylphosphonate with copper (I) catalysis to afford diethyl (4-iodophenyl) difluoromethylphosphonate. Higher yielding couplings were run ...
