Stereoselective synthesis and antifungal activities of (E)-α-(methoxyimino) benzeneacetate derivatives containing 1, 3, 5-substituted pyrazole ring

…, HQ Zhang, J Liu, XP Yang, ZJ Liu

文献索引：Li, Yan; Zhang, Hong-Quan; Liu, Jie; Yang, Xiang-Ping; Liu, Zhao-Jie Journal of Agricultural and Food Chemistry, 2006 , vol. 54, # 10 p. 3636 - 3640

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被引用次数: 108

摘要

Thirteen novel (E)-α-(methoxyimino) benzeneacetate derivatives, the analogues of strobilurins, which contain two pharmacophoric substructures of the methyl (E)- methoxyiminoacetate moiety and 1, 3, 5-substituted pyrazole ring, were stereoselectively synthesized. It was found that the coupling reaction could give stereoselectively (E: Z ca. 14: 1) the key intermediate material (E)-methyl 2-(hydroxyimino)-2-o-tolyl acetate (2). An X-ray ...