Development of a scalable process for DG-041, a potent EP3 receptor antagonist, via tandem heck reactions

S Zegar, C Tokar, LA Enache…

文献索引：Organic Process Research and Development, , vol. 11, # 4 p. 747 - 753

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被引用次数: 31

摘要

... which was necessary for removal of the substantial byproducts generated using the Bartoli procedure. ... Over the course of our process development work, significant efficiencies were achieved. ... and extracted with 2 L of diethylether, which was added to the original organic phase. ...