Synthesis, absolute stereochemistry and molecular design of the new antifungal and antibacterial antibiotic produced by Streptomyces sp. 201

…, NC Barua, JC Borah, S Mazumder, D Thakur…

文献索引：Boruwa; Kalita; Barua; Borah; Mazumder; Thakur; Gogoi; Bora Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 13 p. 3571 - 3574

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被引用次数: 26

摘要

The absolute stereochemistry of the new antifungal and antibacterial antibiotic produced by Streptomyces sp. 201 has been established by achieving the total synthesis of the product. A series of analogues have also been synthesized by changing the side chain and their bioactivity assessed against different microbial strains. Among them, 1e (R= C8H17) was found to be the most potent with MIC of 8μg/mL against Mycobacterium tuberculosis, 12μg ...