Non-natural glycosphingolipids and structurally simpler analogues bind HIV-1 recombinant Gp120

…, JC Conboy, SS Saavedra, J Gervay-Hague

文献索引：McReynolds, Katherine D.; Bhat, Abhijit; Conboy, John C.; Saavedra; Gervay-Hague, Jacquelyn Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 3 p. 625 - 637

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被引用次数: 19

摘要

Interactions of recombinant gp120 (rgp120) with non-natural glycosphingolipids (GSLs) and structurally simpler analogues have been studied using a competitive adhesion assay. Conjugates of cellobiosyl ceramide and melibiosyl ceramide were synthetically prepared as water-soluble GSL analogues. These ligands were screened against a panel of biologically relevant analogues, and the results show that their interactions with rgp120 are ...