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A method for the stereoselective synthesis of (E)-methylstilbene retinoids

MI Dawson, K Derdzinski, PD Hobbs…

文献索引:Dawson; Derdzinski; Hobbs; et al. Journal of Organic Chemistry, 1984 , vol. 49, # 26 p. 5265 - 5267

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被引用次数: 9

摘要

The E isomers of stilbenes 3 are a new class of aromatic retinoids that has shown promising activity in controlling the differentiation of epithelial cells and, therefore, may have potential therapeutic value in the treatment of such proliferative diseases of the skin as cancer, psoriasis, and Highly stereoselective syntheses of (E)-3 are desirable because the E and Z isomers in this series are frequently difficult to separate. We have investigated the ...