Continuous flow hydrogenation using an on-demand gas delivery reactor

MA Mercadante, CB Kelly, C Lee…

文献索引：Mercadante, Michael A.; Kelly, Christopher B.; Lee, Christopher; Leadbeater, Nicholas E. Organic Process Research and Development, 2012 , vol. 16, # 5 p. 1064 - 1068

全文：HTML全文

被引用次数: 25

摘要

A continuous-flow approach to the hydrogenation of alkenes utilizing Wilkinson's catalyst is reported. The approach relies on a newly developed coil design in which it is possible to load gas and heat the reaction mixture simultaneously. The hydrogenation of various substrates has been performed successfully on small scale and can be scaled up substantially.