Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5′-monophosphate decarboxylase

…, AM Bello, E Poduch, Y Liu, CJ Paige…

文献索引：Bello, Angelica M.; Konforte, Danijela; Poduch, Ewa; Furlonger, Caren; Wei, Lianhu; Liu, Yan; Lewis, Melissa; Pai, Emil F.; Paige, Christopher J.; Kotra, Lakshmi P. Journal of Medicinal Chemistry, 2009 , vol. 52, # 6 p. 1648 - 1658

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被引用次数: 6

摘要

Fluorinated nucleosides and nucleotides are of considerable interest to medicinal chemists because of their antiviral, anticancer, and other biological activities. However, their direct interactions at target binding sites are not well understood. A new class of 2′-deoxy-2′- fluoro-C6-substituted uridine and UMP derivatives were synthesized and evaluated as inhibitors of orotidine 5′-monophosphate decarboxylase (ODCase or OMPDCase). ...