Nitration of 3-acylindoles in the presence of metal MeCN solvates and synthesis of the antibiotic alkaloid chuangxinmycin.

…, T KOIKE, Y MORIYA, S TOBINAGA

文献索引：Murase; Koike; Moriya; Tobinaga Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 7 p. 2656 - 2660

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被引用次数: 12

摘要

Nitration of 3-acylindoles in the presence of MeCN solvates of Cu 2+, Al 3+, and Fe 2+ salts yielded 3-nitroindole, 4-nitro-and 6-nitro-3-acylindoles, of which 3-acetyl-4-nitroindole was subsequently transformed into dehydrochuangxinmycin (7), the dehydro derivative of the antibiotic alkaloid chuangxinmycin (2).