Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer

DJ Hwang, J Yang, H Xu, IM Rakov, ML Mohler…

文献索引：Hwang, Dong Jin; Yang, Jun; Xu, Huiping; Rakov, Igor M.; Mohler, Michael L.; Dalton, James T.; Miller, Duane D. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 19 p. 6525 - 6538

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被引用次数: 34

摘要

A new series of androgen receptor targeted agents (ARTA) was prepared and tested in androgen-dependent and-independent prostate cancer cell lines. These agents were bicalutamide analogs with isothiocyanato substituted B-rings. Also, the linker sulfone of R- bicalutamide was maintained or replaced with several alternative linkages including ether, amine, N-methylamine, thioether, and methylene (in this case the product was a racemic ...