The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity

…, M Martín-Martínez, E Cenarruzabeitia…

文献索引：Alonso De Diego, Sergio A.; Gutierrez-Rodriguez, Marta; Perez de Vega, M. Jesus; Gonzalez-Muniz, Rosario; Herranz, Rosario; Martin-Martinez, Mercedes; Cenarruzabeitia, Edurne; Frechilla, Diana; Rio, Joaquin Del; Jimeno, M. Luisa; Garcia-Lopez, M. Teresa Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3396 - 3400

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被引用次数: 21

摘要

The influence of several modifications on the GPE tripeptide structure upon the binding to GluRs and on their neuroprotective effects has been studied. The results indicated that the prevention of neuronal death showed by GPE and some analogues is not directly related to their affinity at glutamate receptors.