Stereochemical considerations and the antiinflammatory activity of 6-amino-6, 7, 8, 9-tetrahydro-5H-benzocyclohepten-5-ols and related derivatives

…, S Sasso, H Jones, JJ Kaminski

文献索引：Wong; Sasso; Jones; Kaminski Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 20 - 27

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被引用次数: 10

摘要

The antiinflammatory activity of a series of 6-amino-6, 7, 8, 9-tetrahydro-5H- benzocyclohepten-5-ols and related derivatives was examined using the reverse passive Arthus reaction (RPAR). The antiinflammatory activity of these compounds was markedly influenced by the stereochemistry of the amino alcohol moiety. The threo diastereomer exhibited activity in the RPAR, while the erythro diastereomer was devoid of any ...