Abstract Cefcapene pivoxil monohydrochloride monohydrate, a broad spectrum third- generation cephalosporin for oral administration, was prepared by reacting three centers of 7β-amino-3-(hydroxymethyl) cephalosporinic acid (7-HACA), derived from 7β- aminocephalosporanic acid. The coupling of 7-HACA and (Z)-2-[2-(Boc-amino) thiazol-4-yl] pent-2-enoic acid, followed by carbamylation with chlorosulfonyl isocyanate, and ...
![(6R,7R)-7-((Z)-2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)pent-2-enamido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid结构式](https://image.chemsrc.com/caspic/045/153012-25-0.png)
![tert-butyl (4-((Z)-1-(((5aR,6R)-1,7-dioxo-1,3,4,5a,6,7-hexahydroazeto[2,1-b]furo[3,4-d][1,3]thiazin-6-yl)amino)-1-oxopent-2-en-2-yl)thiazol-2-yl)carbamate结构式](https://image.chemsrc.com/caspic/191/1360188-88-0.png)
