Novel indole-2-carboxamide and cycloalkeno [1, 2-b] indole derivatives. Structure-activity relationships for high inhibition of human LDL peroxidation

…, D Bonnefont-Rousselot, JG Bizot-Espiard…

文献索引：Kuehm-Caubere, Catherine; Caubere, Paul; Jamart-Gregoire, Brigitte; Negre-Salvayre, Anne; Bonnefont-Rousselot, Dominique; Bizot-Espiard, Jean-Guy; Pfeiffer, Bruno; Caignard, Daniel-Henri; Guardiola-Lemaitre, Beatrice; Renard, Pierre Journal of Medicinal Chemistry, 1997 , vol. 40, # 8 p. 1201 - 1210

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被引用次数: 14

摘要

Series of indole-2-carboxamide and cycloalkeno [1, 2-b] indole derivatives were synthesized and evaluated in order to determine the necessary structural requirements for a high inhibition of human LDL copper-induced peroxidation. Various modulations were systematically performed on the indole and cycloalkeno [1, 2-b] indole nuclei as well as on the carboxamide moiety. The best compounds (3c, 3e, 7c, 7f, 7h, 7g, and 7o) are between ...