Synthesis and hypoglycemic evaluation of substituted pyrazole-4-carboxylic acids

B Cottineau, P Toto, C Marot, A Pipaud…

文献索引：Cottineau, Bertrand; Toto, Patrick; Marot, Christophe; Pipaud, Aline; Chenault, Jacques Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 16 p. 2105 - 2108

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被引用次数: 176

摘要

The synthesis and in vivo activities of a series of substituted pyrazole-4-carboxylic acids as hypoglycemic agents are described. Modelization of some potent compounds, comparatively to the metformine, presents certain analogies permitting to predict the design of some novel antidiabetic drugs.