Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-Gram-positive activity

JP Surivet, C Zumbrunn, G Rueedi…

文献索引：Journal of Medicinal Chemistry, , vol. 56, # 18 p. 7396 - 7415

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被引用次数: 20

摘要

... Journal of Medicinal Chemistry. ... At the dawn of the 21st century, it was common belief that genomic and associated new technologies would deliver a plethora of new antibacterial drug targets(5, 6) and, thus, new chemical entities lacking cross-resistance with clinically used ...