Synthesis and β-blocking activity of (R, S)-(E)-oximeethers of 2, 3-dihydro-1, 8-naphthyridine and 2, 3-dihydrothiopyrano [2, 3-b] pyridine: identification of β 3- …

…, V Calderone, T Cavallini, PL Ferrarini, R Greco…

文献索引：Saccomanni, Giuseppe; Badawneh, Muwaffag; Adinolfi, Barbara; Calderone, Vincenzo; Cavallini, Tiziana; Ferrarini, Pier Luigi; Greco, Rosamiria; Manera, Clementina; Testai, Lara Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 4921 - 4931

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被引用次数: 14

摘要

Drugs acting on β1-and β2-adrenergic receptors are widely used for the clinical management of a large number of cardiovascular and respiratory pathologies. In the last decade, the discovery of the third subtype of β receptors, the β3-adrenoceptor, gave a further pharmacological target for the development of new selective drugs. Initially, a potential therapeutic use of β3-selective agents seemed to be restricted to agonists, for the ...