Synthesis and antiproliferative activity of 7-azaindirubin-3′-oxime, a 7-aza isostere of the natural indirubin pharmacophore

M Kritsanida, P Magiatis, AL Skaltsounis…

文献索引：Kritsanida, Marina; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Peng, Youyi; Li, Peng; Wennogle, Lawrence P. Journal of Natural Products, 2009 , vol. 72, # 12 p. 2199 - 2202

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被引用次数: 30

摘要

The bis-indole alkaloid indirubin and its analogues bear a very interesting natural pharmacophore. They are recognized mainly as kinase inhibitors, but several other activities make them possible candidates for preclinical studies. Based on the previously reported activity of 7-bromoindirubin-3′-oxime and its derivatives, the synthesis of indirubins bearing a heterocyclic nitrogen atom at position 7 was carried out. Herein, we report the first ...