Tetrahedron

Design, synthesis and transformation of some heteroannulated 3-aminopyridines—purine isosteres with exocyclic nitrogen atom

VO Iaroshenko, M Vilches-Herrera, A Gevorgyan…

文献索引：Iaroshenko, Viktor O.; Vilches-Herrera, Marcelo; Gevorgyan, Ashot; Mkrtchyan, Satenik; Arakelyan, Knar; Ostrovskyi, Dmytro; Abbasi, Muhammad S.A.; Supe, Linda; Hakobyan, Ani; Villinger, Alexander; Volochnyuk, Dmitriy M.; Tolmachev, Andrei Tetrahedron, 2013 , vol. 69, # 3 p. 1217 - 1228

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被引用次数: 7

摘要

The synthesis of 1-deazapurines and isosteres bearing the exocyclic nitrogen atom at position-1 was developed basing on the formal [3+ 3]-cyclization reaction of nitro- malonaldehyde with the set of electron-excessive aminoheterocycles. Through the functionalization of the purine-like scaffolds synthesized the diversity of compounds furnished in the possition-1 with aryl, alkinyl, and vinyl rests, were obtained.