Tetrahedron

New and highly efficient synthesis of 3-substituted 1-hydroxybenz [g] isoquinoline-5, 10-diones

…, S Claessens, BM Mbala, K Huygen, N De Kimpe

文献索引：Claessens, Sven; Jacobs, Jan; De Kimpe, Norbert Synlett, 2007 , # 5 p. 741 - 744

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被引用次数: 17

摘要

A new and efficient strategy for the synthesis of 3-substituted 1-hydroxybenz [g] isoquinoline- 5, 10-diones by reaction of 2-methoxycarbonyl-1, 4-naphthoquinone with different pyridinium salts under Kröhnke conditions is disclosed. This one-step reaction was found to be dependent on the substitution pattern of the aromatic nucleus in the pyridinium salts.