Ginger and its bioactive component inhibit enterotoxigenic Escherichia coli heat-labile enterotoxin-induced diarrhea in mice

JC Chen, LJ Huang, SL Wu, SC Kuo…

文献索引：Chen, Jaw-Chyun; Huang, Li-Jiau; Wu, Shih-Lu; Kuo, Sheng-Chu; Ho, Tin-Yun; Hsiang, Chien-Yun Journal of Agricultural and Food Chemistry, 2007 , vol. 55, # 21 p. 8390 - 8397

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被引用次数: 70

摘要

Ginger is one of the most commonly used fresh herbs and spices. Enterotoxigenic Escherichia coli heat-labile enterotoxin (LT)-induced diarrhea is the leading cause of infant death in developing countries. In this study, we demonstrated that ginger significantly blocked the binding of LT to cell-surface receptor GM1, resulting in the inhibition of fluid accumulation in the closed ileal loops of mice. Biological-activity-guided searching for ...