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Structure-mutagenicity relationships of N-oxidized derivatives of aniline, o-toluidine, 2'-methyl-4-aminobiphenyl, and 3, 2'-dimethyl-4-aminobiphenyl

…, K El-Bayoumy, L Tulley, E LaVoie

文献索引:Hecht; El-Bayoumy; Tulley; LaVoie Journal of Medicinal Chemistry, 1979 , vol. 22, # 8 p. 981 - 987

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被引用次数: 43

摘要

A series of N-oxidized derivatives of aniline (la), 2'-methyl-4-aminobiphenyl (5a), and the carcinogens o-toluidine (lb) and 3, 2'-dimethyl-4-aminobiphenyl (5b) were prepared and tested for mutagenic activity toward S. typhimurium. The compounds tested were the hydroxylamines 2a, b and 6a, b; C-nitroso compounds 3a, b and 7a, b; and the hydroxamic acids 4a, b and 8a, b derived from the amines la, b and 5a, b, as well as the parent amines ...