Tetrahedron letters

Chiral 5-(diphenylphosphanyl)-1, 2, 3, 4-tetrahydroacridines: new N, P-ligands for asymmetric catalysis

G Chelucci, G Orrù

文献索引：Chelucci, Giorgio; Orru, Gianmauro Tetrahedron Letters, 2005 , vol. 46, # 20 p. 3493 - 3496

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被引用次数: 15

摘要

Three chiral 5-(diphenylphosphanyl)-1, 2, 3, 4-tetrahydroacridines, as first representative examples of a new class of chiral N, P-ligands were prepared from (+)-nopinone,(+)- camphor and 5α-androst-2-en-17-one. These ligands have been assessed in the enantioselective palladium-catalysed allylic substitution of 1, 3-diphenylprop-2-enyl acetate with dimethyl malonate. Enantioselectivity up to 74% has been obtained.