4-Substituted 4-(1H-1, 2, 3-triazol-1-yl) piperidine: Novel C7 moieties of fluoroquinolones as antibacterial agents

X Huang, A Zhang, D Chen, Z Jia, X Li

文献索引：Huang, Xiaoguang; Zhang, Aiqin; Chen, Dongliang; Jia, Zhenhua; Li, Xingshu Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 9 p. 2859 - 2863

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被引用次数: 34

摘要

A series of 4-substituted 4-(1H-1, 2, 3-triazol-1-yl) piperidine building blocks was synthesized and introduced to the C7 position of the quinolone core, 7-chloro-1-cyclopropyl- 6-fluoro-4-oxo-1, 4-dihydro-1, 8-naphthyridine-3-carboxylic acid, to afford the corresponding fluoroquinolones in 40–83% yield. The antibacterial activity of these new fluoroquinolones was evaluated using a standard broth microdilution technique. Among them, the ...