Antitumor agents 259. Design, syntheses, and structure-activity relationship study of desmosdumotin C analogs

K Nakagawa-Goto, TH Chen, CY Peng…

文献索引：Nakagawa-Goto, Kyoko; Wu, Jiu-Hong; Lee, Kuo-Hsiung Synthetic Communications, 2005 , vol. 35, # 13 p. 1735 - 1739

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被引用次数: 11

摘要

Desmosdumotin C (1) and its analogs previously showed potent, selective in vitro anticancer activity. To explore structure-activity relationships of 1 and further increase potency and selectivity, 15 novel analogs (7-15 and 21-26) were synthesized and evaluated for cytotoxity