Biaryl synthesis via Pd-catalyzed decarboxylative coupling of aromatic carboxylates with aryl halides

…, N Rodríguez, B Melzer, C Linder, G Deng…

文献索引：Goossen, Lukas J.; Rodriguez, Nuria; Melzer, Bettina; Linder, Christophe; Deng, Guojun; Levy, Laura M. Journal of the American Chemical Society, 2007 , vol. 129, # 15 p. 4824 - 4833

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被引用次数: 353

摘要

A new strategy for the regiospecific construction of unsymmetrical biaryls is presented, in which easily available salts of carboxylic acids are decarboxylated in situ to give arylmetal species that serve as the nucleophilic component in a catalytic cross-coupling reaction with aryl halides. The catalyst system consists of a copper phenanthroline complex that mediates the extrusion of CO2 from aromatic carboxylates to generate arylcopper species, and a ...

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