Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo [1, 2-a] pyridine symbiotic prototypes

…, CKF de Lima, LL da Silva, NC Romeiro…

文献索引：Lacerda, Renata B.; de Lima, Cleverton K.F.; da Silva, Leandro L.; Romeiro, Nelilma C.; Miranda, Ana Luisa P.; Barreiro, Eliezer J.; Fraga, Carlos A.M. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 74 - 84

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被引用次数: 89

摘要

We describe herein the design, synthesis and pharmacological evaluation of novel 3- arylamine-imidazo [1, 2-a] pyridine derivatives structurally designed as novel symbiotic prototypes presenting analgesic and anti-inflammatory properties. The derivatives obtained were submitted to in vivo assays of nociception, hyperalgesia and inflammation, and to in vitro assays of human PGHS-2 inhibition. These assays allowed the identification of ...