Efficient Approach to 4??Benzyl??5, 5??dimethyldihydrofuranones: Total Synthesis of (±_bold;)??Solafuranone

A Srikrishna, G Satyanarayana…

文献索引：Srikrishna; Satyanarayana; Desai, Uday V. Synthetic Communications, 2007 , vol. 37, # 6 p. 965 - 976

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被引用次数: 5

摘要

Abstract A six??step general and very efficient synthesis of 4??(arylmethyl)??5, 5?? dialkyldihydrofuranones starting from corresponding aryl aldehyde has been developed. Solafuranone, a novel furanone isolated from the Chinese folk medicine Solanum indicum, has been accomplished starting from 2, 6??dimethylbenzaldehyde in six steps in an overall yield of 70%. Contrary to expectations, solafuranone and its analogue failed to exhibit any ...