1-Phenyl-3-amino-1, 2, 3, 4-tetrahydronaphthalenes and Related Derivatives as Ligands for the Neuromodulatory. sigma. 3 Receptor: Further Structure-Activity …

…, AM Myers, CE Owens, EC Bucholtz…

文献索引：Wyrick, Steven D.; Booth, Raymond G.; Myers, Andrew M.; Owens, Constance E.; Bucholtz, Ehren C.; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3857 - 3864

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被引用次数: 21

摘要

A series of l-phenyl-3-amino-1, 2, 3, 4-tetrahydronaphthalenes (l-pheny1-3-aminotetralins, PATs) previously was found to stimulate tyrosine hydroxylase activity and dopamine synthesis in rat brain through interaction with a novel u3 receptor. Specifically, the trans-lR, BS-(-) isomer of H2-PAT showed highest affinity for 03 receptors and also produced maximal stimulation of tyrosine hydroxylase activity and dopamine synthesis, as compared to the ...