An improved procedure for the synthesis of naphthalene amino alcohols is described. Four new compounds were prepared and tested by Rane Laboratories for activitj. i's. P/n., n? odiiini hwghei in mice.. Ill compounds were active. the most active being l-[~ i-14- chlorophenylI-5.7-d~ chl~~ rc~-l-naphthyl]-~~-~ d~-~~-butylarn~ no~ pr~ ipan1~ l hydrochloride i 16b). Structure-activity relationships betwren the naphthalene and ...
