European journal of medicinal chemistry

NMR studies of N-(benzimidazol-2-yl) pyridinium derivatives: QSAR with the anti-leishmanial activity and their carbon-13 NMR chemical shifts

E Alcalde, I Dinarés, J Frigola

文献索引：Alcalde, E; Dinares, I; Frigola, J European Journal of Medicinal Chemistry, 1991 , vol. 26, # 6 p. 633 - 642

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被引用次数: 13

摘要

Abstract Quantitative structure-activity—relationships between the in vitro anti-leishmanial activity of N-benzimidazolyl-2, 4, 6-triphenylpyridinium salts 6 and pyridinium benzimidazolate betaines 7 and their 13 C-NMR chemical shifts have been studied, in order to ascertain the influence of the benzimidazole substituents upon anti-leishmanial activity. The calculated 13 C-chemical shifts allow the selection of a representative subset of ...