Molecular harpoons. Membrane-disruptive surfactants that can recognize osmotic stress in phospholipid bilayers

K Naka, A Sadownik, SL Regen

文献索引：Naka, Kensuke; Sadownik, Andrzej; Regen, Steven L. Journal of the American Chemical Society, 1993 , vol. 115, # 6 p. 2278 - 2286

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被引用次数: 29

摘要

Abstract: A series of wedge-shaped, nonionic surfactant molecules (molecular harpoons) have been synthesized and used to disrupt large unilamellar vesicles derived from 1- palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), POPC/cholesterol (2/l), and POPC/cholesterol (55/45), under isotonic and hypotonic (osmotically stressed) conditions. The activity of each surfactant has been defined by measuring its ability to release vesicle- ...