Allosteric inhibition of fructose-1, 6-bisphosphatase by anilinoquinazolines

SW Wright, DL Hageman, LD McClure, AA Carlo…

文献索引：Wright, Stephen W.; Hageman, David L.; McClure, Lester D.; Carlo, Anthony A.; Treadway, Judith L.; Mathiowetz, Alan M.; Withka, Jane M.; Bauer, Paul H. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 1 p. 17 - 21

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被引用次数: 37

摘要

Anilinoquinazolines currently of interest as inhibitors of tyrosine kinases have been found to be allosteric inhibitors of the enzyme fructose 1, 6-bisphosphatase. These represent a new approach to inhibition of F16BPase and serve as leads for further drug design. Enzyme inhibition is achieved by binding at an unidentified allosteric site.