Design, synthesis and biological evaluation of 2-substituted quinolines as potential antileishmanial agents

…, J Pinjari, RT Dere, A Verma, P Vishwakarma…

文献索引：Gopinath, Vadiraj S.; Pinjari, Jakir; Dere, Ravindra T.; Verma, Aditya; Vishwakarma, Preeti; Shivahare, Rahul; Moger, Manjunath; Kumar Goud, Palusa Sanath; Ramanathan, Vikram; Bose, Prosenjit; Rao; Gupta, Suman; Puri, Sunil K.; Launay, Delphine; Martin, Denis European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 527 - 536

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被引用次数: 31

摘要

Abstract An analogous library of 2-substituted quinoline compounds was synthesized with the aim to identify a potential drug candidate to treat visceral leishmaniasis. These molecules were tested for their in vitro and in vivo biological activity against Leishmania donovani. Metabolic stability of these compounds was also improved through the introduction of halogen substituents. Compound (26g), found to be the most active; ...